Cheryl has been captured by the True Eye cult and is locked inside of a storage closet. She is about to be sacrificed by Sean Keanan, leader of the cult, when Frank arrives to their rescue. After Sean is killed, Frank is able to open the closet where Cheryl is locked up and frees her, along with the other four hostages.
After being rescued, she will wait in the room with the blue door. When Ronald Shiner complains about the lack of food, he rallies up the other survivors in the same room, including Cheryl, to head out and look for food.
If Frank does not stop Ronald's mutiny, Cheryl will leave the Security Room along with the other survivors in the same room. They will no longer count towards the number of rescued survivors.
If Cheryl is saved, she will later have a personal request for Frank. When asked about her request, Cheryl asks that Frank capture her on film. When Frank asks why, she answers that she has no idea how things will turn out and that she does not want to die without leaving an image of herself behind. She poses in a series of provocative poses while Frank photographs her.
An unused model present on Xbox 360 Dead Rising discs shows Cheryl holding her breasts and spreading her legs while lying on her back. It can be inferred that this model was intended to be a pose from Cheryl's Request. Though no nudity is present, this model is likely absent in-game due to over-exposure of Cheryl's crotch region, which would have affected the game's ESRB rating.