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- "I'm getting the hell out of this city, I'm taking my friends with me."
- —Nick Ramos
Nick Ramos is the playable protagonist of Dead Rising 3.
Nick is a mechanic who works for Wrench O' Rama in the fictional city of Los Perdidos. He was an orphan and has no recollection of his early childhood years. He has a mysterious, unknown past. One of the few things he remembers was that he always had a tattoo of the number 12 on the right side of his neck. 
He, along with other survivors, seeks a means to escape Los Perdidos before it is firebombed by the military. He travels with his boss and owner of Wrench O' Rama Rhonda and a truck driver Dick throughout the city and combine their efforts to escape Los Perdidos within the six day time limit, before the announced bombing by the military is set to occur. During the course of the game, it is discovered Nick is naturally immune or resistant to the zombie infection, as shown by his bite wounds healing instead of festering.
Nick is the youngest Dead Rising protagonist so far, allowing him to grow more as the story develops. In the beginning stages of the outbreak, Nick comes off as a naive and somewhat cowardly young man who has difficulties formulating plans. His intentions, however, are always good: he always puts people's thoughts and needs before his own. Nick begins to develop a sense of purpose as he fights for survival during his time spent in Los Perdidos.
He has a romantic interest in Annie, and at the end of the game, the two begin a relationship.
Before the outbreak begins, Nick is driving a car to a customer for his job at Wrench O' Rama. He meets a young woman named Annie, who he believes at first to be another customer. While initially attempting to flirt with her, he soon realizes that she is actually stealing the car, and chases after her. But before he can, they are both swarmed by a sudden horde of zombies.
They manage to work together to escape, before running into another survivor, Dick Baker, and the three attempt to leave the city. This is when they realize that a full scale outbreak has begun, and the government has already quarantined the city. Annie is also revealed to be an infected illegal. They meet up with Nick's boss Rhonda and attempt to find shelter in a diner.
Dead Rising 3
- Main article: Story Mode (Dead Rising 3)
During the events of Dead Rising 3, Nick attempts escape the city with a group of survivors before the military deploys a large incendiary bomb, destroying all organic life in the city. The bomb is to be deployed in 6 days from the game's beginning.
Nick and Rhonda work together to rebuild an old military plane so that they can use it to leave before Los Perdidos is bombed. It is later revealed by Isabela Keyes that he is one of Carlito Keyes' orphans from the Santa Cabeza outbreak, known as "number 12", and his blood contains the cure for the zombie infection.
- Nick is the only protagonist to have only survived one major outbreak. Both Frank West and Chuck Greene lead him by three major outbreaks, Frank West has survived the 2006 Willamette outbreak, the 2011 Fortune City outbreak (Case West), and the 2022 Willamette outbreak. While Chuck Greene has survived the 2008 Las Vegas Outbreak, the 2011 Fortune City outbreak, and the 2021 Los Perdidos outbreak (The Still Creek & Phenotrans Facility outbreak are technically minor outbreaks).
- Nick is the first Latino protagonist in the Dead Rising series, which subsequently makes him the Dead Rising series' first non-Caucasian protagonist as well.
- Nick's tattoo suggests that he is the twelfth of Carlito's Orphans, yet the twelfth orphan on the list found in Dead Rising is a female by the name of Lisa Jackson. It could be speculated that Carlito's list of orphans on his computer was false, and used as a way to cover his own tracks or he may have infected other orphans as a back up plan in case any of his original bunch died of other causes before they could turn. It's also possible the list is coded as number 21, the inversion of 12, lists a Juan Rodriguez approximately the same age and ethnicity as Nick--Names were possibly changed as part of the adoption process or to facilitate anonymity for Carlito's plan.
- Nick is the first protagonist who does not wear a watch.
- Nick's first name ends with a "K", like the other main protagonists from Dead Rising and Dead Rising 2.
- Nick has a spade-shaped patch on his coveralls sleeve which reads "Terror Is Reality", a reference to the game show from Dead Rising 2.
- On the wanted poster found by Red, it says that Nick is between the ages of 18 and 24 years old, making him the youngest playable protagonist thus far in the series.
- Judging by Isabela's story of the orphans, Nick's father was in the US military and his mother was a native to Santa Cabeza.
- Nick's signature weapon is the Sledge Saw.
- Nick was originally named Mack before becoming Nick.
- Nick and Annie are the only two characters to kiss in the entirety (of the video games installments) of the Dead Rising series so far, save Chuck Greene and his wife in Dead Rising: Road to Fortune.
- In the cinematic trailer, Nick does not have the number 12 tattoo
- Xbox Dead Rising 3 Information Xbox.com
- Dead Rising 3 Details www.siliconera.com
- Dead Rising 3 Set in California, Protagonist is an Auto Mechanic www.siliconera.com
- Dead Rising 3 Details Revealed IGN.com