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It is unlocked by completing 72 Hour Mode with a total of fifty or more survivors rescued. Frank may only have Simone Ravendark or Dr. Barnaby survive. If Frank stops before Case 6-1 Barnaby survives, but if Frank keeps playing Barnaby will die and Frank will be able to keep Simone.
In order to obtain the Saint achievement, at least fifty survivors must be saved at the end of 72 Hour Mode. For a full list of survivors that can be rescued, see Dead Rising Survivors.
- The maximum number of survivors that can be rescued at the end of Ending A is forty-nine. Thus, it is impossible to finish 72 Hour Mode with Ending A and obtain Saint at the same time. However, by completing Overtime Mode directly after obtaining Ending A, Saint can be unlocked.
- Although Ed DeLuca is alive and safe at the end of Endings B and E, he does not count towards the total number of survivors saved, and thus does not count towards the Saint achievement.
- Should Carlito's bombs go off, all the survivors will die, costing you the achievement.
- Frank (you) will count as 1 survivor as well if you make it to the helicopter for an escape.